| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 21/01/25 18:45 | AS Monaco | Aston Villa | 1-0 |
| 21/01/25 18:45 | Atalanta Bergamo | SK Sturm Graz | 5-0 |
| 21/01/25 21:00 | FC Liverpool | LOSC Lille | 2-1 |
| 21/01/25 21:00 | Atletico Madrid | Bayer 04 Leverkusen | 2-1 |
| 21/01/25 21:00 | FC Bruges | Juventus Turin | 0-0 |
| 21/01/25 21:00 | Etoile Rouge Belgrade | PSV Eindhoven | 2-3 |
| 21/01/25 21:00 | SK Slovan Bratislava | VfB Stuttgart | 1-3 |
| 21/01/25 21:00 | FC Bologna | Borussia Dortmund | 2-1 |
| 21/01/25 21:00 | Benfica Lisbonne | FC Barcelone | 4-5 |
| 22/01/25 18:45 | Shakhtar Donetsk | Stade Brestois 29 | 2-0 |
| 22/01/25 18:45 | RB Leipzig | Sporting Lisbonne | 2-1 |
| 22/01/25 21:00 | FC Arsenal | Dinamo Zagreb | 3-0 |
| 22/01/25 21:00 | AC Milan | FC Girona | 1-0 |
| 22/01/25 21:00 | Real Madrid | Red Bull Salzbourg | 5-1 |
| 22/01/25 21:00 | Paris Saint-Germain | Manchester City | 4-2 |
| 22/01/25 21:00 | Celtic Glasgow | Young Boys Bern | 1-0 |
| 22/01/25 21:00 | Feyenoord Rotterdam | Bayern Munich | 3-0 |
| 22/01/25 21:00 | Sparta Prag | Inter Milan | 0-1 |